SP-0577: Clinical evidence of spatially variable proton biological effectiveness in pediatric brain tumour patients
نویسندگان
چکیده
منابع مشابه
Clinical evidence of variable proton biological effectiveness in pediatric patients treated for ependymoma.
BACKGROUND AND PURPOSE A constant relative biological effectiveness (RBE) is used for clinical proton therapy; however, experimental evidence indicates that RBE can vary. We analyzed pediatric ependymoma patients who received proton therapy to determine if areas of normal tissue damage indicated by post-treatment image changes were associated with increased biological dose effectiveness. MATE...
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Proton relative biological effectiveness (RBE) is known to depend on the (α/β)x of irradiated tissues, with evidence of ∼60% variation over (α/β)x values from 1-10 Gy. The range of (α/β)x values reported for prostate tumors (1.2-5.0 Gy), brain tumors (10-15 Gy) and liver tumors (13-17 Gy) imply that the proton RBE for these tissues could vary significantly compared to the commonly used generic ...
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15 صفحه اولAnalysis of Relative Biological Effectiveness of Proton Beams and Iso-effective Dose Profiles Using Geant4
Background: The assessment of RBE quantity in the treatment of cancer tumors with proton beams in treatment planning systems (TPS) is of high significance. Given the significance of the issue and the studies conducted in the literature, this quantity is fixed and is taken as equal to 1.1.Objective: The main objective of this study was to assess RBE quantity of proton beams and their variations ...
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ژورنال
عنوان ژورنال: Radiotherapy and Oncology
سال: 2018
ISSN: 0167-8140
DOI: 10.1016/s0167-8140(18)30887-9